"Nature vs. Nurture" is the thirteenth episode and finale of the first season of The Spectacular Spider-Man. It was written by Kevin Hopps and directed by Victor Cook. The episode originally aired on June 14, 2008.
After getting rid of the symbiote, Spider-Man (Josh Keaton) stops a group of well-armed jewelry thieves (This is actually the original trailer for the series repurposed for the show). He goes by Tombstone's (Kevin Michael Richardson) office and returns the money he got while under the symbiote's influence saying he won't work for him. After the hero leaves, an enormous black Spider-Man-like figure (Benjamin Diskin) appears offering to take the job the wallcrawler refused. Tombstone orders the figure to kill Spider-Man and "they" agree.
Peter goes to the hospital where his Aunt May (Deborah Strang) is recovering from her heart attack. He uses the moment to remind himself that "With great power comes great responsibility." At high school, he attempts to apologize to his friends and fellow students, and they pass off his symbiote-induced behavior as stress related to his aunt. Liz Allan (Alanna Ubach) invites him to help with the balloon the school has during the parade the next day. Peter declines as he will be taking Aunt May home. Mary Jane Watson (Vanessa Marshall) then tells Peter that she and Eddie Brock went out on a date but he seemed to do it more for spite than love. Peter calls Eddie, who is actually the mysterious black figure, who offers to "hang out" later.
Peter and Gwen Stacy (Lacey Chabert) visit the hospital where Peter offers to help May by making the Thanksgiving Day dinner, though the two women are skeptical. Peter tries to cook but starts burning everything. Later, he considers using the gene cleanser to rid himself of the powers that cause him so many problem. Just then he yanked into his backyard by Eddie. He introduces himself as Venom as he is poison to Spider-Man. Venom proves himself stronger, faster, with more powerful webbing, the ability to elude his Spider-Sense, and knows everything Peter does. Venom then promises to hurt the one he loves most.
Venom beats Spider-Man to the hospital. Spider-Man attacks before his foe can hurt his aunt but is once again overpowered. Venom teases he will go after someone Peter loves more than May. Thinking he means Mary Jane, Spider-Man races to the Thanksgiving Day parade to save her. Spider-Man finds Mary Jane talking with Flash, safe and sound, then sees that Eddie has gone after Gwen instead. Spider-Man tries to get to Gwen, who has been webbed to a parade balloon, but Venom attacks once more overpowering him. Mary Jane and Flash spot Gwen and rally their friends to use a balloon as a net to catch her should she fall.
Spider-Man rescues Gwen and brings her to safety. He resumes his losing battle against Venom and gets him away from the crowds. Spider-Man then gets the symbiote to leave Eddie by offering himself saying he is the one the symbiote really wants. Once rejoined, the symbiote again tries to assault his mind. However, Peter uses the memory of his friends and loved ones to reject the alien creature. Once separated, Eddie is knocked out and the symbiote is vulnerable. Spider-Man scoops it up and drops it into drying cement when no one is looking.
Later, Peter finds that May's doctor (Dorian Harewood) brought her home in his absence. Just then, Gwen and her father George (Clancy Brown) arrive with food for the Thanksgiving feast. May had thought Peter would need help with the dinner and she insisted on coming despite her hostage situation. After finishing dessert, May laments that the hospital bill will eat up most of the check she got from the publishing company, a check for a cookbook she is writing. She admits that she had been working herself so hard for this book. While doing dishes, Peter considers his life as Spider-Man and all that it has done for him, finally pouring the gene cleanser down the drain. Later, as George is packing the car to return home Gwen kisses Peter on the lips. As they leave, Peter thinks of Venom's word about the one he loves the most.
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