The S.H.I.E.L.D. Space Shuttle is a spaceship designed by S.H.I.E.L.D. on the planet Earth. The members of the Illuminati used one shuttle to capture Bruce Banner, also known as the Hulk, to send him to another planet. Hulk woke and damaged the ship. It then went through a wormhole and crashed on the planet Sakaar. Hulk escaped but was forced into the gladiator games by the Sakaar Natives. They put an Obedience Disk on him and infected him with talkbots so he could be manageable.
In the comics, the shuttle eventually blew up, destroyed much of Sakaar, and killed Caiera who was carrying Hulk's child. Having blamed the Illuminati for all the death and destruction, Hulk returned to Earth and forced the Earth heroes into gladiator combat with each other.